SUGIHARA F, INOUE N, KUWAMORI K, TANIGUCHI M.
Bioavailability trials revealed that two types of Wellnex collagen dipeptides, hydroxyproline (Pro-Hyp) and hydroxyproline-glycine (Hyp-Gly), were available at high concentrations in the human blood stream after oral consumption.
KAWAGUCHI T, NANBU P.N, KUROKAWA M.
One of the key dipeptides, proline-hydroxyproline (Pro-Hyp), could be found within skin cells and bone tissue after ingestion. "...distributed in tissues including skin and cartilage in its intact form... which might be responsible for its biological functions."
OHARA H, ICHIKAWA S, MATSUMOTO H, AKIYAMA M, FUJIMOTO N, KOBAYASHI T, TAJIMA S.
Results of an in vitro study using dermal fibroblasts display the ability of the dipeptide proline-hydroxyproline (Pro-Hyp) to enhance "cellular proliferation (1.5fold) and hyaluronic synthesis (3.8 fold) at a dose of 200nmol/mL."
LIU C, SUGITA K, NIHEI K,N, YONEYAMA K, TANAKA H.
Findings suggest that Pro-Hyp and Hyp-Gly are stable and relatively resistant to peptidases in the blood and demonstrate that collagen peptides are able to reach the skin tissues. "...significant amount of these peptides was transported across the intestinal wall..."