Collagen Research

Scientific studies and findings

Clinical Studies

Test showed decreased UV spot area ratio after consumption over 8 weeks.
Our skin may contain many hidden spots created by the harmful damage of UV rays. Collagen peptides can help eliminate these spots and led to a clearer complexion.
Test showed improved moisture and texture levels after consumption over 8 weeks.
 
Up to 70% of skin is made from collagen. Collagen peptides work by improving skin structure which leads to smoother skin texture and a higher level of moisture.
Test showed increased pain relief to knees over consumption of 13 weeks.
 
Our collagen peptides have been proven to reduce knee discomfort by preventing joint cartilage and bone cell deformation through both laboratory mice and human clinical studies.
Test showed increased pain relief to knee osteoarthritis over consumption of 13 weeks.
 
Our collagen peptides have been proven to reduce knee discomfort by preventing joint cartilage and bone cell deformation through both laboratory mice and human clinical studies.
Test found bone mineral density to stay approximately 30-50% higher over a 3 week consumption.
 
Laboratory mice studies indicate that our collagen peptides encourage healthy bone metabolism and are a supplement to help potentially prevent and treat bone diseases such as osteoporosis.

Research

SUGIHARA F, INOUE N, KUWAMORI K, TANIGUCHI M.


Bioavailability trials revealed that two types of Wellnex collagen dipeptides, proline-hydroxyproline (Pro-Hyp) and hydroxyproline-glycine (Hyp-Gly), were available at high concentrations in the human blood stream after oral consumption.

KAWAGUCHI T, NANBU P.N, KUROKAWA M.


One of the key di-peptides, proline-hydroxyproline (Pro-Hyp), could be found within skin cells and bone tissue after ingestion. "...distributed in tissues including skin and cartilage in its intact form...which might be responsible for its biological functions."

LIU C, SUGITA K, NIHEI K,N, YONEYAMA K, TANAKA H.


Findings suggest that Pro-Hyp and Hyp-Gly are stable and relatively resistant to peptidases in the blood and demonstrate that collagen peptides are able to reach the skin tissues. "...a significant amount of these peptides was transported across the intestinal wall and may enter the portal circulation in an intact form."

OHARA H, ICHIKAWA S, MATSUMOTO H, AKIYAMA M, FUJIMOTO N, KOBAYASHI T, TAJIMA S.


Results of an in vitro study using dermal fibroblasts display the ability of the dipeptide proline-hydroxyproline (Pro-Hyp) to enhance "cellular proliferation (1.5fold) and hyaluronic acid synthesis (3.8fold) at a dose of 200nmol/mL."

LEE H.J, JANG H.L, AHN D.K, KIM H.J, JEON H.Y, SEO D.B, LEE J.H, CHOI J.K, KANG S.S.


The collagen peptide consumption protects against UVB-induced skin aging and exerts beneficial effects on skin health. "...significantly reduced UVB-induced wrinkle formation, transepidermal water loss, and epidermis thickness, and increased skin hydration.

YAZAKI M, ITO Y, YAMADA M, GOULAS S, TERAMOTO S, NAKAYA M.A, OHNO S, YAMAGUCHI K.


Functional peptides can be transferred to the skin by dietary supplements of collagen.

KANG M.C, YUMNAM S, KIM S.Y.


Results show that oral administration of collagen peptides increases hyaluronic acid levels that decreases during UVB photoaging. Therefore, collagen peptide consumption can be used as a nutricosmetic ingredient with potential effects on UVB-induced skin dehydration and moisture loss in addition to wrinkle formation.

OBA C, OHARA H, MORIFUJI M, ITO K, ICHIKAWA S, KAWAHATA K, KOGA J.


"Administration of collagen hydrolysate significantly decreased transepidermal water loss, epidermal hyperplasia, and a decrease in statum corneum water content" damage to the skin induced by Ultraviolet B irradiation. It can improve skin elasticity and dermal hyaluronic acid content.