This research suggests that Nobiletin (a flavonoid found in Shikuwasa fruit) has the potential to become a novel drug for the treatment and prevention of neurodegenerative diseases such as AD and PD.
MAHMOUD A.M., BAUTISTA R.J.H., SANDHU M.A., HUSSEIN O.E.
Citrus flavonoids possess several biological activities and have emerged as efficient therapeutics for the treatment of Cardiovascular Disease. The intake of citrus flavonoids has been associated with improved cardiovascular outcomes.
WANG YUE., LIU X.J., CHEN J.B., CAO J.P., LI XIAN, SUN C.D.
Citrus flavonoids play an essential role in regulating oxidative stress and are an important source of daily intake of antioxidant supplements. Many studies have shown that citrus flavonoids promote health through antioxidation.
Tangeretin, a flavone found in Shikuwasa fruit, has shown potent anti-cancer activity in different types of cancer cells.
TEJADA S., PINYA S., MARTORELL M., CAPO X., A TUR J., PONS A., SUREDA A.
Hesperidin is a flavonoid present in high concentration in Shikuwasa and has numerous biological properties, principally antioxidant and anti-inflammatory.